A tunable artificial circadian clock in clock-defective mice

Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design...

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Udgivet i:Nat Commun
Main Authors: D'Alessandro, Matthew, Beesley, Stephen, Kim, Jae Kyoung, Chen, Rongmin, Abich, Estela, Cheng, Wayne, Yi, Paul, Takahashi, Joseph S., Lee, Choogon
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674671/
https://ncbi.nlm.nih.gov/pubmed/26617050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9587
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