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A tunable artificial circadian clock in clock-defective mice

Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: D'Alessandro, Matthew, Beesley, Stephen, Kim, Jae Kyoung, Chen, Rongmin, Abich, Estela, Cheng, Wayne, Yi, Paul, Takahashi, Joseph S., Lee, Choogon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674671/
https://ncbi.nlm.nih.gov/pubmed/26617050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9587
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