RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven adenocarcinomas

Non-small cell lung cancer (NSCLC) often expresses mutant KRAS together with tumor-associated mutations of the CDKN2A locus, which are associated with aggressive, therapy-resistant tumors. Here, we unravel specific requirements for the maintenance of NSCLC that carry this genotype. We establish that...

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Bibliografische gegevens
Hoofdauteurs: Konstantinidou, Georgia, Ramadori, Giorgio, Torti, Francesca, Kangasniemi, Kim, Ramirez, Rachel E., Cai, Yiran, Behrens, Carmen, Dellinger, Michael T., Brekken, Rolf A., Wistuba, Ignacio I., Heguy, Adriana, Teruya-Feldstein, Julie, Scaglioni, Pier Paolo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625467/
https://ncbi.nlm.nih.gov/pubmed/23358651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0388
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