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Hypoxia induces a phase transition within a kinase signaling network in cancer cells

Hypoxia is a near-universal feature of cancer, promoting glycolysis, cellular proliferation, and angiogenesis. The molecular mechanisms of hypoxic signaling have been intensively studied, but the impact of changes in oxygen partial pressure (pO(2)) on the state of signaling networks is less clear. I...

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Detalhes bibliográficos
Main Authors: Wei, Wei, Shi, Qihui, Remacle, Francoise, Qin, Lidong, Shackelford, David B., Shin, Young Shik, Mischel, Paul S., Levine, R. D., Heath, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625329/
https://ncbi.nlm.nih.gov/pubmed/23530221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303060110
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