Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

To define genetic lesions driving leukemia, we targeted cre-dependent Sleeping Beauty (SB) transposon mutagenesis to the blood-forming system using a hematopoietic-selective vav 1 oncogene (vav1) promoter. Leukemias of diverse lineages ensued, most commonly lymphoid leukemia and erythroleukemia. The...

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Autori principali: Tang, Jian Zhong, Carmichael, Catherine L., Shi, Wei, Metcalf, Donald, Ng, Ashley P., Hyland, Craig D., Jenkins, Nancy A., Copeland, Neal G., Howell, Viive M., Zhao, Zhizhuang Joe, Smyth, Gordon K., Kile, Benjamin T., Alexander, Warren S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625293/
https://ncbi.nlm.nih.gov/pubmed/23533276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304234110
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