Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

To define genetic lesions driving leukemia, we targeted cre-dependent Sleeping Beauty (SB) transposon mutagenesis to the blood-forming system using a hematopoietic-selective vav 1 oncogene (vav1) promoter. Leukemias of diverse lineages ensued, most commonly lymphoid leukemia and erythroleukemia. The...

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Detalhes bibliográficos
Main Authors: Tang, Jian Zhong, Carmichael, Catherine L., Shi, Wei, Metcalf, Donald, Ng, Ashley P., Hyland, Craig D., Jenkins, Nancy A., Copeland, Neal G., Howell, Viive M., Zhao, Zhizhuang Joe, Smyth, Gordon K., Kile, Benjamin T., Alexander, Warren S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625293/
https://ncbi.nlm.nih.gov/pubmed/23533276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304234110
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