Gene Expression Patterns of Hemizygous and Heterozygous KIT Mutations Suggest Distinct Oncogenic Pathways: A Study in NIH3T3 Cell Lines and GIST Samples

OBJECTIVE: Most gain of function mutations of tyrosine kinase receptors in human tumours are hemizygous. Gastrointestinal stromal tumours (GIST) with homozygous mutations have a worse prognosis. We aimed to identify genes differentially regulated by hemizygous and heterozygous KIT mutations. MATERIA...

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Main Authors: Bachet, Jean-Baptiste, Tabone-Eglinger, Séverine, Dessaux, Sophie, Besse, Anthony, Brahimi-Adouane, Sabrina, Emile, Jean-François, Blay, Jean-Yves, Alberti, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625162/
https://ncbi.nlm.nih.gov/pubmed/23593401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061103
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