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Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A()
Twenty eight new analogues were synthesized by optimizing the structure of MP-10 and their in vitro binding affinities towards PDE10A, PDE3A/B, and PDE4A/B were determined. Among these new analogues, 10a, 10b, 10d, 11a, 11b and 11d are very potent towards PDE10A and have IC(50) values of 0.40 ± 0.02...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625062/ https://ncbi.nlm.nih.gov/pubmed/23585921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD20239E |
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