Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes

The determinants of HIV-1-associated lymphadenopathy are poorly understood. We hypothesized that lymphocytes could be sequestered in the HIV-1+ lymph node (LN) through impairments in sphingosine-1-phosphate (S1P) responsiveness. To test this hypothesis, we developed novel assays for S1P-induced Akt...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Mudd, Joseph C., Murphy, Patrick, Manion, Maura, Debernardo, Robert, Hardacre, Jeffrey, Ammori, John, Hardy, Gareth A., Harding, Clifford V., Mahabaleshwar, Ganapati H., Jain, Mukesh K., Jacobson, Jeffrey M., Brooks, Ari D., Lewis, Sharon, Schacker, Timothy W., Anderson, Jodi, Haddad, Elias K., Cubas, Rafael A., Rodriguez, Benigno, Sieg, Scott F., Lederman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2013
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624937/
https://ncbi.nlm.nih.gov/pubmed/23422746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-445783
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares