Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes

The determinants of HIV-1-associated lymphadenopathy are poorly understood. We hypothesized that lymphocytes could be sequestered in the HIV-1+ lymph node (LN) through impairments in sphingosine-1-phosphate (S1P) responsiveness. To test this hypothesis, we developed novel assays for S1P-induced Akt...

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Hlavní autoři: Mudd, Joseph C., Murphy, Patrick, Manion, Maura, Debernardo, Robert, Hardacre, Jeffrey, Ammori, John, Hardy, Gareth A., Harding, Clifford V., Mahabaleshwar, Ganapati H., Jain, Mukesh K., Jacobson, Jeffrey M., Brooks, Ari D., Lewis, Sharon, Schacker, Timothy W., Anderson, Jodi, Haddad, Elias K., Cubas, Rafael A., Rodriguez, Benigno, Sieg, Scott F., Lederman, Michael M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624937/
https://ncbi.nlm.nih.gov/pubmed/23422746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-445783
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