Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes

The determinants of HIV-1-associated lymphadenopathy are poorly understood. We hypothesized that lymphocytes could be sequestered in the HIV-1+ lymph node (LN) through impairments in sphingosine-1-phosphate (S1P) responsiveness. To test this hypothesis, we developed novel assays for S1P-induced Akt...

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Detalhes bibliográficos
Main Authors: Mudd, Joseph C., Murphy, Patrick, Manion, Maura, Debernardo, Robert, Hardacre, Jeffrey, Ammori, John, Hardy, Gareth A., Harding, Clifford V., Mahabaleshwar, Ganapati H., Jain, Mukesh K., Jacobson, Jeffrey M., Brooks, Ari D., Lewis, Sharon, Schacker, Timothy W., Anderson, Jodi, Haddad, Elias K., Cubas, Rafael A., Rodriguez, Benigno, Sieg, Scott F., Lederman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624937/
https://ncbi.nlm.nih.gov/pubmed/23422746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-445783
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