Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes

The determinants of HIV-1-associated lymphadenopathy are poorly understood. We hypothesized that lymphocytes could be sequestered in the HIV-1+ lymph node (LN) through impairments in sphingosine-1-phosphate (S1P) responsiveness. To test this hypothesis, we developed novel assays for S1P-induced Akt...

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Detaylı Bibliyografya
Asıl Yazarlar: Mudd, Joseph C., Murphy, Patrick, Manion, Maura, Debernardo, Robert, Hardacre, Jeffrey, Ammori, John, Hardy, Gareth A., Harding, Clifford V., Mahabaleshwar, Ganapati H., Jain, Mukesh K., Jacobson, Jeffrey M., Brooks, Ari D., Lewis, Sharon, Schacker, Timothy W., Anderson, Jodi, Haddad, Elias K., Cubas, Rafael A., Rodriguez, Benigno, Sieg, Scott F., Lederman, Michael M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2013
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624937/
https://ncbi.nlm.nih.gov/pubmed/23422746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-445783
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