The Frequency of CD127(+) Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection

T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expressi...

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Main Authors: Shin, Eui-Cheol, Park, Su-Hyung, Nascimbeni, Michelina, Major, Marian, Caggiari, Laura, de Re, Valli, Feinstone, Stephen M., Rice, Charles M., Rehermann, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624391/
https://ncbi.nlm.nih.gov/pubmed/23388706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03122-12
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