The Frequency of CD127(+) Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection

T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expressi...

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Bibliographische Detailangaben
Hauptverfasser: Shin, Eui-Cheol, Park, Su-Hyung, Nascimbeni, Michelina, Major, Marian, Caggiari, Laura, de Re, Valli, Feinstone, Stephen M., Rice, Charles M., Rehermann, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624391/
https://ncbi.nlm.nih.gov/pubmed/23388706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03122-12
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