A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity but Not the Transmission of Egyptian Highly Pathogenic H5N1 Influenza Virus in Chickens

Highly pathogenic avian influenza (HPAI) virus H5N1 has been enzootic in Egypt since 2008. Virus-associated mortality (but not the number of cases) in humans and poultry seems to have decreased over time, but the reason for this remains unknown. We investigated the role of a single amino acid substi...

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Bibliografiska uppgifter
Huvudupphovsmän: Yoon, Sun-Woo, Kayali, Ghazi, Ali, Mohamed A., Webster, Robert G., Webby, Richard J., Ducatez, Mariette F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2013
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624353/
https://ncbi.nlm.nih.gov/pubmed/23408622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03551-12
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