Amino Acid Substitutions in PB1 of Avian Influenza Viruses Influence Pathogenicity and Transmissibility in Chickens

Amino acid substitutions were introduced into avian influenza virus PB1 in order to characterize the interaction between polymerase activity and pathogenicity. Previously, we used recombinant viruses containing the hemagglutinin (HA) and neuraminidase (NA) genes from the highly pathogenic avian infl...

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Detalhes bibliográficos
Main Authors: Suzuki, Yasushi, Uchida, Yuko, Tanikawa, Taichiro, Maeda, Naohiro, Takemae, Nobuhiro, Saito, Takehiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178826/
https://ncbi.nlm.nih.gov/pubmed/25031333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01564-14
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