Increased Acid Stability of the Hemagglutinin Protein Enhances H5N1 Influenza Virus Growth in the Upper Respiratory Tract but Is Insufficient for Transmission in Ferrets

Influenza virus entry is mediated by the acidic-pH-induced activation of hemagglutinin (HA) protein. Here, we investigated how a decrease in the HA activation pH (an increase in acid stability) influences the properties of highly pathogenic H5N1 influenza virus in mammalian hosts. We generated isoge...

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Bibliographische Detailangaben
Hauptverfasser: Zaraket, Hassan, Bridges, Olga A., Duan, Susu, Baranovich, Tatiana, Yoon, Sun-Woo, Reed, Mark L., Salomon, Rachelle, Webby, Richard J., Webster, Robert G., Russell, Charles J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754100/
https://ncbi.nlm.nih.gov/pubmed/23824818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01175-13
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