Increased Acid Stability of the Hemagglutinin Protein Enhances H5N1 Influenza Virus Growth in the Upper Respiratory Tract but Is Insufficient for Transmission in Ferrets

Influenza virus entry is mediated by the acidic-pH-induced activation of hemagglutinin (HA) protein. Here, we investigated how a decrease in the HA activation pH (an increase in acid stability) influences the properties of highly pathogenic H5N1 influenza virus in mammalian hosts. We generated isoge...

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Hlavní autoři: Zaraket, Hassan, Bridges, Olga A., Duan, Susu, Baranovich, Tatiana, Yoon, Sun-Woo, Reed, Mark L., Salomon, Rachelle, Webby, Richard J., Webster, Robert G., Russell, Charles J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754100/
https://ncbi.nlm.nih.gov/pubmed/23824818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01175-13
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