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Amino Acid Residues in the Fusion Peptide Pocket Regulate the pH of Activation of the H5N1 Influenza Virus Hemagglutinin Protein

The receptor specificity and cleavability of the hemagglutinin (HA) protein have been shown to regulate influenza A virus transmissibility and pathogenicity, but little is known about how its pH of activation contributes to these important biological properties. To identify amino acid residues that...

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Autors principals: Reed, Mark L., Yen, Hui-Ling, DuBois, Rebecca M., Bridges, Olga A., Salomon, Rachelle, Webster, Robert G., Russell, Charles J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663236/
https://ncbi.nlm.nih.gov/pubmed/19193808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02238-08
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