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Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress

Human cytomegalovirus (HCMV) encodes one conventional protein kinase, UL97. During infection, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites ordinarily phosphorylated by cyclin-dependent kinases (CDK), inactivating the ability of pRb to repress host genes required for...

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書誌詳細
主要な著者: Reim, Natalia I., Kamil, Jeremy P., Wang, Depeng, Lin, Alison, Sharma, Mayuri, Ericsson, Maria, Pesola, Jean M., Golan, David E., Coen, Donald M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624322/
https://ncbi.nlm.nih.gov/pubmed/23427156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00007-13
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