Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress

Human cytomegalovirus (HCMV) encodes one conventional protein kinase, UL97. During infection, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites ordinarily phosphorylated by cyclin-dependent kinases (CDK), inactivating the ability of pRb to repress host genes required for...

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Detalhes bibliográficos
Main Authors: Reim, Natalia I., Kamil, Jeremy P., Wang, Depeng, Lin, Alison, Sharma, Mayuri, Ericsson, Maria, Pesola, Jean M., Golan, David E., Coen, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624322/
https://ncbi.nlm.nih.gov/pubmed/23427156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00007-13
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