Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

NY-ESO-1 and LAGE-1 are cancer testis antigens with an ideal profile for tumor immunotherapy, combining up-regulation in many cancer types with highly restricted expression in normal tissues and sharing a common HLA-A*0201 epitope, 157–165. Here, we present data to describe the specificity and anti-...

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Main Authors: McCormack, Emmet, Adams, Katherine J., Hassan, Namir J., Kotian, Akhil, Lissin, Nikolai M., Sami, Malkit, Mujić, Maja, Osdal, Tereza, Gjertsen, Bjørn Tore, Baker, Deborah, Powlesland, Alex S., Aleksic, Milos, Vuidepot, Annelise, Morteau, Olivier, Sutton, Deborah H., June, Carl H., Kalos, Michael, Ashfield, Rebecca, Jakobsen, Bent K.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624013/
https://ncbi.nlm.nih.gov/pubmed/23263452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-012-1384-4
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