IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals

The IL-27R, WSX-1, is required to limit IFN-γ production by effector CD4(+) T cells in a number of different inflammatory conditions but the molecular basis of WSX-1-mediated regulation of Th1 responses in vivo during infection has not been investigated in detail. In this study we demonstrate that W...

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Main Authors: Villegas-Mendez, Ana, de Souza, J. Brian, Lavelle, Seen-Wai, Gwyer Findlay, Emily, Shaw, Tovah N., van Rooijen, Nico, Saris, Christiaan J., Hunter, Christopher A., Riley, Eleanor M., Couper, Kevin N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623720/
https://ncbi.nlm.nih.gov/pubmed/23593003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003293
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