Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

BACKGROUND: Activating mutations [internal tandem duplication (ITD)] or overexpression of the FMS-like tyrosine kinase receptor-3 (FLT3) gene are associated with poor outcome in acute myeloid leukemia (AML) patients, underscoring the need for novel therapeutic approaches. The natural product silvest...

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Detalhes bibliográficos
Main Authors: Alachkar, Houda, Santhanam, Ramasamy, Harb, Jason G, Lucas, David M, Oaks, Joshua J, Hickey, Christopher J, Pan, Li, Kinghorn, A Douglas, Caligiuri, Michael A, Perrotti, Danilo, Byrd, John C, Garzon, Ramiro, Grever, Michael R, Marcucci, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623627/
https://ncbi.nlm.nih.gov/pubmed/23497456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-21
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