Use of a Bacteriophage Lysin to Identify a Novel Target for Antimicrobial Development

We identified an essential cell wall biosynthetic enzyme in Bacillus anthracis and an inhibitor thereof to which the organism did not spontaneously evolve measurable resistance. This work is based on the exquisite binding specificity of bacteriophage-encoded cell wall-hydrolytic lysins, which have e...

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Autors principals: Schuch, Raymond, Pelzek, Adam J., Raz, Assaf, Euler, Chad W., Ryan, Patricia A., Winer, Benjamin Y., Farnsworth, Andrew, Bhaskaran, Shyam S., Stebbins, C. Erec, Xu, Yong, Clifford, Adrienne, Bearss, David J., Vankayalapati, Hariprasad, Goldberg, Allan R., Fischetti, Vincent A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622686/
https://ncbi.nlm.nih.gov/pubmed/23593301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060754
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