Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents

[Image: see text] We present the discovery and optimization of a novel series of inhibitors of bacterial UDP-N-acetylglucosamine 2-epimerase (called 2-epimerase in this letter). Starting from virtual screening hits, the activity of various inhibitory molecules was optimized using a combination of st...

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Bibliographic Details
Main Authors: Xu, Yong, Brenning, Benjamin, Clifford, Adrianne, Vollmer, David, Bearss, Jared, Jones, Carissa, McCarthy, Virgil, Shi, Chongtie, Wolfe, Bradley, Aavula, Bhasker, Warner, Steve, Bearss, David J., McCullar, Michael V., Schuch, Raymond, Pelzek, Adam, Bhaskaran, Shyam S., Stebbins, C. Erec, Goldberg, Allan R., Fischetti, Vincent A., Vankayalapati, Hariprasad
Format: Artigo
Language:Inglês
Published: American Chemical Society 2013
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890692/
https://ncbi.nlm.nih.gov/pubmed/24443700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4001936
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