Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis

The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) plays a key role in sialic acid production. It is different from the non-hydrolyzing enzymes for bacterial cell wall biosynthesis, and it is feed-back inhibited by the downstream product CMP-Neu5Ac. Here the complex crystal structure...

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Pubblicato in:Sci Rep
Autori principali: Chen, Sheng-Chia, Huang, Chi-Hung, Lai, Shu-Jung, Yang, Chia Shin, Hsiao, Tzu-Hung, Lin, Ching-Heng, Fu, Pin-Kuei, Ko, Tzu-Ping, Chen, Yeh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793188/
https://ncbi.nlm.nih.gov/pubmed/26980148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23274
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