Use of a Bacteriophage Lysin to Identify a Novel Target for Antimicrobial Development

We identified an essential cell wall biosynthetic enzyme in Bacillus anthracis and an inhibitor thereof to which the organism did not spontaneously evolve measurable resistance. This work is based on the exquisite binding specificity of bacteriophage-encoded cell wall-hydrolytic lysins, which have e...

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Hlavní autoři: Schuch, Raymond, Pelzek, Adam J., Raz, Assaf, Euler, Chad W., Ryan, Patricia A., Winer, Benjamin Y., Farnsworth, Andrew, Bhaskaran, Shyam S., Stebbins, C. Erec, Xu, Yong, Clifford, Adrienne, Bearss, David J., Vankayalapati, Hariprasad, Goldberg, Allan R., Fischetti, Vincent A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622686/
https://ncbi.nlm.nih.gov/pubmed/23593301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060754
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