Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin

Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease. Thus, the identification of amyloid precursor protein binding proteins involved in regulating processing of...

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Autors principals: Stemmer, Nina, Strekalova, Elena, Djogo, Nevena, Plöger, Frank, Loers, Gabriele, Lutz, David, Buck, Friedrich, Michalak, Marek, Schachner, Melitta, Kleene, Ralf
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621835/
https://ncbi.nlm.nih.gov/pubmed/23585889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061299
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