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Generation and intracellular trafficking of a polysialic acid-carrying fragment of the neural cell adhesion molecule NCAM to the cell nucleus

Polysialic acid (PSA) and its major protein carrier, the neural cell adhesion molecule NCAM, play important roles in many nervous system functions during development and in adulthood. Here, we show that a PSA-carrying NCAM fragment is generated at the plasma membrane by matrix metalloproteases and t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Westphal, Nina, Loers, Gabriele, Lutz, David, Theis, Thomas, Kleene, Ralf, Schachner, Melitta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561184/
https://ncbi.nlm.nih.gov/pubmed/28819302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09468-8
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