Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1(+/–) mice

Solar ultraviolet B (UVB) radiation induces cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives continued proliferation and clonal expansion of initiated (mutated) cells, leading to tumorigenesis. Therefore ODC is a potentially important targ...

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Detalhes bibliográficos
Main Authors: Tang, Xiuwei, Kim, Arianna L., Feith, David J., Pegg, Anthony E., Russo, Justin, Zhang, Hong, Aszterbaum, Michelle, Kopelovich, Levy, Epstein, Ervin H., Bickers, David R., Athar, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC362123/
https://ncbi.nlm.nih.gov/pubmed/15067319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420732
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