Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1(+/–) mice

Solar ultraviolet B (UVB) radiation induces cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives continued proliferation and clonal expansion of initiated (mutated) cells, leading to tumorigenesis. Therefore ODC is a potentially important targ...

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Pubblicato in:J Clin Invest
Autori principali: Tang, Xiuwei, Kim, Arianna L., Feith, David J., Pegg, Anthony E., Russo, Justin, Zhang, Hong, Aszterbaum, Michelle, Kopelovich, Levy, Epstein, Ervin H., Bickers, David R., Athar, Mohammad
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2004
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Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362123/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15067319/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20732
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