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Monoubiquitination of nuclear RelA negatively regulates NF-κ activity independent of proteasomal degradation

Termination and resolution of inflammation is tightly linked to the inactivation of one of its strongest inducers, NF-κB. While canonical post-stimulus inactivation is achieved by upregulation of inhibitory molecules that relocate NF-κB complexes to the cytoplasm, termination of the NF-κB response c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hochrainer, Karin, Racchumi, Gianfranco, Zhang, Sheng, Iadecola, Costantino, Anrather, Josef
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621033/
https://ncbi.nlm.nih.gov/pubmed/22261743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-011-0912-2
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