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The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation

Activation of NF-κB-dependent transcription represents an important hallmark of inflammation. While the acute inflammatory response is per se beneficial, it can become deleterious if its spatial and temporal profile is not tightly controlled. Classically, NF-κB activity is limited by cytoplasmic ret...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hochrainer, Karin, Pejanovic, Nadja, Olaseun, Victoria A., Zhang, Sheng, Iadecola, Costantino, Anrather, Josef
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787756/
https://ncbi.nlm.nih.gov/pubmed/26476452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1064
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