The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation

Activation of NF-κB-dependent transcription represents an important hallmark of inflammation. While the acute inflammatory response is per se beneficial, it can become deleterious if its spatial and temporal profile is not tightly controlled. Classically, NF-κB activity is limited by cytoplasmic ret...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Hochrainer, Karin, Pejanovic, Nadja, Olaseun, Victoria A., Zhang, Sheng, Iadecola, Costantino, Anrather, Josef
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Molecular Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787756/
https://ncbi.nlm.nih.gov/pubmed/26476452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1064
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