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Hypo-phosphorylation leads to nuclear retention of NF-κB p65 due to impaired IκBα gene synthesis
Subcellular localization guided by IκBα is crucial for regulation of NF-κB function. Here we show that p65 RHD phosphorylation mutants are transported into the nucleus after IκBα degradation, but as a consequence of lower IκBα levels their relocation to the cytosol is blocked. We demonstrate that ph...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2149890/ https://ncbi.nlm.nih.gov/pubmed/17991436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.10.056 |
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