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Role of SHIP1 in cancer and mucosal inflammation

The SH-2 containing inositol 5’ polyphosphatase 1 (SHIP1) is a multifunctional protein expressed predominantly, by hematopoietic cells. SHIP1 removes the 5’ phosphate from the product of PI3K, PI(3,4,5)P(3), to generate PI(3,4)P(2). Both PIP species influence the activity level of Akt, and ultimatel...

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Bibliografske podrobnosti
Main Authors: Fernandes, Sandra, Iyer, Sonia, Kerr, William G.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620675/
https://ncbi.nlm.nih.gov/pubmed/23551094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12038
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