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Role of SHIP1 in cancer and mucosal inflammation

The SH-2 containing inositol 5’ polyphosphatase 1 (SHIP1) is a multifunctional protein expressed predominantly, by hematopoietic cells. SHIP1 removes the 5’ phosphate from the product of PI3K, PI(3,4,5)P(3), to generate PI(3,4)P(2). Both PIP species influence the activity level of Akt, and ultimatel...

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Bibliografiske detaljer
Main Authors: Fernandes, Sandra, Iyer, Sonia, Kerr, William G.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620675/
https://ncbi.nlm.nih.gov/pubmed/23551094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12038
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