Bortezomib (PS-341) Treatment Decreases Inflammation and Partially Rescues the Expression of the Dystrophin-Glycoprotein Complex in GRMD Dogs

Golden retriever muscular dystrophy (GRMD) is a genetic myopathy corresponding to Duchenne muscular dystrophy (DMD) in humans. Muscle atrophy is known to be associated with degradation of the dystrophin-glycoprotein complex (DGC) via the ubiquitin-proteasome pathway. In the present study, we investi...

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Hlavní autoři: Araujo, Karla P. C., Bonuccelli, Gloria, Duarte, Caio N., Gaiad, Thais P., Moreira, Dayson F., Feder, David, Belizario, José E., Miglino, Maria A., Lisanti, Michael P., Ambrosio, Carlos E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620287/
https://ncbi.nlm.nih.gov/pubmed/23579193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061367
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