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Overexpression of Full-Length Centrobin Rescues Limb Malformation but Not Male Fertility of the Hypodactylous (hd) Rats

Rat hypodactyly (hd) mutation is characterized by abnormal spermatogenesis and sperm decapitation, limb malformation (missing digits II and III) and growth retardation. We have previously reported centrobin (centrosome BRCA2-interacting protein) truncation at the C-terminus in the hd mutant. Here, w...

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Detalhes bibliográficos
Main Authors: Liška, František, Gosele, Claudia, Popova, Elena, Chylíková, Blanka, Křenová, Drahomíra, Křen, Vladimír, Bader, Michael, Tres, Laura L., Hubner, Norbert, Kierszenbaum, Abraham L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620055/
https://ncbi.nlm.nih.gov/pubmed/23577170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060859
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