Rat hd Mutation Reveals an Essential Role of Centrobin in Spermatid Head Shaping and Assembly of the Head-Tail Coupling Apparatus

The hypodactylous (hd) locus impairs limb development and spermatogenesis, leading to male infertility in rats. We show that the hd mutation is caused by an insertion of an endogenous retrovirus into intron 10 of the Cntrob gene. The retroviral insertion in hd mutant rats disrupts the normal splicin...

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Detalhes bibliográficos
Main Authors: Liška, František, Gosele, Claudia, Rivkin, Eugene, Tres, Laura, Cardoso, M. Cristina, Domaing, Petra, Krejčí, Eliška, Šnajdr, Pavel, Lee-Kirsch, Min Ae, de Rooij, Dirk G., Křen, Vladimír, Křenová, Drahomíra, Kierszenbaum, Abraham L., Hubner, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802234/
https://ncbi.nlm.nih.gov/pubmed/19710508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.078980
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