Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging

In mouse and man Y chromosome deletions are frequently associated with spermatogenic defects. Mice with extensive deletions of non-pairing Y chromosome long arm (NPYq) are infertile and produce sperm with grossly misshapen heads, abnormal chromatin packaging and DNA damage. The NPYq-encoded multi-co...

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Autores principales: Riel, Jonathan M., Yamauchi, Yasuhiro, Sugawara, Atsushi, Li, Ho Yan J., Ruthig, Victor, Stoytcheva, Zoia, Ellis, Peter J. I., Cocquet, Julie, Ward, Monika A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619810/
https://ncbi.nlm.nih.gov/pubmed/23178944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.114488
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