Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

Skeletal muscle atrophy is a debilitating response to fasting, disuse, cancer, and other systemic diseases. In atrophying muscles, the ubiquitin ligase, atrogin-1 (MAFbx), is dramatically induced, and this response is necessary for rapid atrophy. Here, we show that in cultured myotubes undergoing at...

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Main Authors: Sandri, Marco, Sandri, Claudia, Gilbert, Alex, Skurk, Carsten, Calabria, Elisa, Picard, Anne, Walsh, Kenneth, Schiaffino, Stefano, Lecker, Stewart H., Goldberg, Alfred L.
Format: Artigo
Jezik:Inglês
Izdano: 2004
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619734/
https://ncbi.nlm.nih.gov/pubmed/15109499
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