PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

Maintaining muscle size and fiber composition requires contractile activity. Increased activity stimulates expression of the transcriptional coactivator PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α), which promotes fiber-type switching from glycolytic toward more oxidative fib...

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Autori principali: Sandri, Marco, Lin, Jiandie, Handschin, Christoph, Yang, Wenli, Arany, Zoltan P., Lecker, Stewart H., Goldberg, Alfred L., Spiegelman, Bruce M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637570/
https://ncbi.nlm.nih.gov/pubmed/17053067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607795103
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