Preemptive priming readily overcomes structure-based mechanisms of virus escape

A reverse-genetics approach has been used to probe the mechanism underlying immune escape for influenza A virus-specific CD8(+) T cells responding to the immunodominant D(b)NP(366) epitope. Engineered viruses with a substitution at a critical residue (position 6, P6M) all evaded recognition by WT D(...

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Detalhes bibliográficos
Main Authors: Valkenburg, Sophie A., Gras, Stephanie, Guillonneau, Carole, Hatton, Lauren A., Bird, Nicola A., Twist, Kelly-Anne, Halim, Hanim, Jackson, David C., Purcell, Anthony W., Turner, Stephen J., Doherty, Peter C., Rossjohn, Jamie, Kedzierska, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619348/
https://ncbi.nlm.nih.gov/pubmed/23493558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302935110
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