Noddy, a Mouse Harboring a Missense Mutation in Protocadherin-15, Reveals the Impact of Disrupting a Critical Interaction Site between Tip-Link Cadherins in Inner Ear Hair Cells

In hair cells of the inner ear, sound or head movement increases tension in fine filaments termed tip links, which in turn convey force to mechanosensitive ion channels to open them. Tip links are formed by a tetramer of two cadherin proteins: protocadherin 15 (PCDH15) and cadherin 23 (CDH23), which...

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Main Authors: Geng, Ruishuang, Sotomayor, Marcos, Kinder, Kimberly J., Gopal, Suhasini R., Gerka-Stuyt, John, Chen, Daniel H.-C., Hardisty-Hughes, Rachel E., Ball, Greg, Parker, Andy, Gaudet, Rachelle, Furness, David, Brown, Steve D., Corey, David P., Alagramam, Kumar N.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618968/
https://ncbi.nlm.nih.gov/pubmed/23467356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4514-12.2013
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