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Structure-based design of an organoruthenium Phosphatidyl-Inositol-3-Kinase inhibitor reveals a switch governing lipid kinase potency and selectivity

Mutations that constitutively activate the PI3K signaling pathway, including alterations in PI3K, PTEN and AKT are found in a variety of human cancers, implicating the PI3K lipid kinase as an attractive target for the development of therapeutic agents to treat cancer and other related diseases. In t...

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書誌詳細
主要な著者: Xie, Peng, Williams, Douglas S., Atilla-Gokcumen, G. Ekin, Milk, Leslie, Xiao, Min, Smalley, Keiran S.M., Herlyn, Meenhard, Meggers, Eric, Marmorstein, Ronen
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618672/
https://ncbi.nlm.nih.gov/pubmed/18484710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb800039y
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