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Aire deficiency promotes TRP-1 specific immune rejection of melanoma

The thymic transcription factor AIRE prevents autoimmunity in part by promoting expression of tissue-specific self-antigens, which include many cancer antigens. For example, AIRE-deficient patients are predisposed to vitiligo, an autoimmune disease of melanocytes that is often triggered by efficacio...

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Detalhes bibliográficos
Main Authors: Zhu, Meng-Lei, Nagavalli, Anil, Su, Maureen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618494/
https://ncbi.nlm.nih.gov/pubmed/23370329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3781
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