CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection

Adenosine triphosphate (ATP), an essential metabolic energy source, is released following cell apoptosis or necrosis. It acts as a damage-associated molecule pattern to stimulate innate immune cells. The ectonucleotidase CD39 regulates immune activation by hydrolysis of extracellular ATP. We have sh...

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Enregistré dans:
Détails bibliographiques
Publié dans:Transpl Immunol
Auteurs principaux: Yoshida, Osamu, Dou, Lei, Kimura, Shoko, Yokota, Shinichiro, Isse, Kumiko, Robson, Simon C., Geller, David A., Thomson, Angus W.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368493/
https://ncbi.nlm.nih.gov/pubmed/25661084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trim.2015.01.003
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