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Nod2-Induced Autocrine Interleukin-1 Alters Signaling by ERK and p38 to Differentially Regulate Secretion of Inflammatory Cytokines

BACKGROUND&AIMS: Stimulation of nucleotide-binding oligomerization domain-containing (Nod)2 and other pattern recognition receptors (PRR) in human monocyte-derived macrophages induces interleukin (IL)-1, which increases mitogen-activated protein kinase (MAPK) activation and cytokine secretion. A...

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Detalhes bibliográficos
Main Authors: Hedl, Matija, Abraham, Clara
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618474/
https://ncbi.nlm.nih.gov/pubmed/22967725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.08.048
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