Altered cerebral protein synthesis in fragile X syndrome: studies in human subjects and knockout mice

Dysregulated protein synthesis is thought to be a core phenotype of fragile X syndrome (FXS). In a mouse model (Fmr1 knockout (KO)) of FXS, rates of cerebral protein synthesis (rCPS) are increased in selective brain regions. We hypothesized that rCPS are also increased in FXS subjects. We measured r...

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Detalhes bibliográficos
Main Authors: Qin, Mei, Schmidt, Kathleen C, Zametkin, Alan J, Bishu, Shrinivas, Horowitz, Lisa M, Burlin, Thomas V, Xia, Zengyan, Huang, Tianjiang, Quezado, Zenaide M, Smith, Carolyn Beebe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618394/
https://ncbi.nlm.nih.gov/pubmed/23299245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.205
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