Altered cerebral protein synthesis in fragile X syndrome: studies in human subjects and knockout mice

Dysregulated protein synthesis is thought to be a core phenotype of fragile X syndrome (FXS). In a mouse model (Fmr1 knockout (KO)) of FXS, rates of cerebral protein synthesis (rCPS) are increased in selective brain regions. We hypothesized that rCPS are also increased in FXS subjects. We measured r...

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Bibliographic Details
Main Authors:	Qin, Mei, Schmidt, Kathleen C, Zametkin, Alan J, Bishu, Shrinivas, Horowitz, Lisa M, Burlin, Thomas V, Xia, Zengyan, Huang, Tianjiang, Quezado, Zenaide M, Smith, Carolyn Beebe
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2013
Subjects:	Original Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3618394/ https://ncbi.nlm.nih.gov/pubmed/23299245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.205
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Altered cerebral protein synthesis in fragile X syndrome: studies in human subjects and knockout mice

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