Noncontiguous regions in the extracellular domain of EGF receptor define ligand-binding specificity.

Murine epidermal growth factor (EGF) binds with approximately 250-fold higher binding affinity to the human EGF receptor (EGFR) than to the chicken EGFR. This difference in binding affinity enabled the identification of a major ligand-binding domain for EGF by studying the binding properties of vari...

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Detalhes bibliográficos

Publicado no:	Cell Regul
Principais autores:	Lax, I, Fischer, R, Ng, C, Segre, J, Ullrich, A, Givol, D, Schlessinger, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Cell Biology 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1716463/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.2.5.337
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